Healthy Volunteers

RAIVEN

This randomized, active comparator trial will compare the clinical efficacy of recombinant influenza vaccine (RIV) to standard-dose egg-based inactivated influenza vaccine (SD IIV) among adults aged 18-64 years. The primary study hypothesis is that the clinical efficacy of RIV is superior to that of SD IIV to prevent and attenuate influenza-like illness (ILI)-associated influenza virus infection.

Primary disease category:

Healthy Volunteers

Secondary disease category(ies):

Healthy Volunteers

Understanding insulin resistance in obesity and type 2 diabetes

The molecular nature of insulin resistance in human muscle is still incompletely defined. For almost thirty years we have been trying to understand the mechanisms that explain why muscle in patients who are obese or have type 2 diabetes only poorly uses fat for fuel. We termed this metabolic inflexibility. This causes fat to build up in muscle and other tissues, and causes the patient to respond poorly to insulin. We now think there are two proteins, called ANT1 and VWA8, that might be responsible for at least part of this.

Primary disease category:

Diabetes & Endocrine System

Secondary disease category(ies):

Healthy Volunteers

Evaluation Study of Eye Conditions or Potential Eye Conditions

This study will allow the University of Arizona (UA) physicians and researchers the opportunity to examine people with or without eye disease, whether the diagnosis is known or not. In this study, no treatment will be offered. Participants undergo various tests and procedures to diagnose or evaluate their eye disease.

Primary disease category:

Eye/Vision

Secondary disease category(ies):

Healthy Volunteers

Control of irregular bleeding with Nexplanon contraceptive implants

Are you interested in trying the Nexplanon contraceptive implant? You may qualify for a research study helping to understand how vaginal bleeding patterns change on the implant and how use of oral contraceptive pills plus the implant can make those bleeding changes more manageable.

Primary disease category:

Women's Health

Secondary disease category(ies):

Healthy Volunteers

An observational study to determine the clinical characteristics in children unlikely to have a pulmonary embolism

No study has been performed to prospectively record the presenting complaints, signs, symptoms and comorbidities of children who raised the suspicion of pulmonary embolism (PE). Clinicians must extrapolate what is known about PE in adults to children. Perhaps as a result, the mortality rate of PE is the same in children as it is in adults. On the other hand, tens of thousands of low risk children and adolescents are unnecessarily exposed to increased lifetime cancer risk from ionizing radiation from CT scans done to search for PE they do not have.

Primary disease category:

Asthma & Lung

Secondary disease category(ies):

Asthma & Lung, Healthy Volunteers

2B-Alert Study

The purpose of this research study is to determine how well individualized caffeine dosing recommendations work to recover performance during continuous extended sleep loss. Results from this study will be used to help develop technology that can be deployed in the field to prevent sleep loss related declines in performance in soldiers. Work has been done to develop models that predict behavior based on previous sleep patterns, but these models have not been tested against laboratory results. This study aims to test how well one specific version of this model works.

Primary disease category:

Healthy Volunteers

Secondary disease category(ies):

Healthy Volunteers

The role of gut microbiome in epilepsy

The propose of this pilot study is to test the hypothesis that children with epilepsy have changes in gut microbiome as compared to their siblings and controls.

Our specific aims are:

1. To compare the taxonomy of gut microbiome in patients with new onset epilepsy versus siblings and controls.

2. To compare the taxonomy of gut microbiome in patients with new onset epilepsy versus chronic and refractory epilepsy.

Primary disease category:

Children, Infants & Newborns

Secondary disease category(ies):

Brain, Spinal Cord & Nervous System, Epilepsy & Seizures, Children, Infants & Newborns, Healthy Volunteers

Tissue Acquisition and Repository for Gastrointestinal and Hepatic Systems (TARGHETS)

Completion of the proposed studies will correlate the specific genes, proteins, nucleic acids or bacterial species with gastrointestinal, pancreato-biliary and hepatology disorders, including but not limited to cancer. A secondary point will be to determine whether specific biomarkers found in bodily fluids or tissue predict qualitative and quantitative changes in metabolic pathways.

Primary disease category:

Digestive System

Secondary disease category(ies):

Digestive System, Healthy Volunteers, Integrative & Complementary Medicine

Improving Medication Adherence with Telehealthcare Medication Therapy Management to Change Health Outcomes in Adolescents and Young Adults with Asthma (MATCH)

Primary disease category:

Asthma & Lung

Secondary disease category(ies):

Asthma & Lung, Children, Infants & Newborns, Healthy Volunteers

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