Sleep Disorders

Comparative Effectiveness of Positive Airway Pressure Therapy, Dental Device, and Atomoxetine-Oxybutynin for Sleep Apnea: the ADAPT-OSA Study

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Researchers want to identify which treatments for obstructive sleep apnea (OSA) work best and are easiest for patients to use consistently. The ADAPT-OSA trial is open to adults who have recently been diagnosed with obstructive sleep apnea (OSA) and live near one of the study sites in Tucson, AZ; Baltimore, MD; Miami, FL; or Palo Alto, CA. Eligible participants will be randomly assigned one of three OSA treatments: traditional PAP therapy, a dental device, or a combination of two FDA-approved medications (atomoxetine and oxybutynin) that are currently approved for other conditions.

Primary disease category: 
Sleep Disorders

REFRESH Study

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This study has two parts.

In Part 1, 15 gynecologic cancer survivors will receive three candidate intervention components known to reduce sleep disturbance (i.e., sleep restriction, stimulus control, systematic light exposure) simultaneously for six weeks. Participants will then complete semi-structured individual interviews to provide feedback about barriers to and facilitators of intervention adherence. Results of Part 1 will inform the design and delivery of the candidate components in Part 2.

Primary disease category: 
Gynecologic Cancers
Secondary disease category(ies): 
Sleep Disorders

Cardiovascular Health and Respiratory Training Study (CHART Study)

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The Arizona Respiratory Neurophysiology Laboratory (ARNL) is investigating the effects of a novel exercise training known as Respiratory Muscle Training (RMT) on sleep and cardiovascular function in adults 50 years of age and older who suffer from obstructive sleep apnea (OSA) and elevated blood pressure.

Primary disease category: 
Sleep Disorders
Secondary disease category(ies): 
Heart/Cardiovascular, Movement & Exercise
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