Heart/Cardiovascular

The REDUCE LAP-HF II study is
evaluating the IASD® System II,
a non-surgical, medical device
designed to improve quality
of life by potentially reducing
breathlessness and fatigue.

MRI Imaging Study

Torsades de pointes (TdP) is a rare life threatening heart arrhythmia. It occurs in individuals with genetic mutations in genes that control the expression of ion channel proteins in the heart and is a frequent cause of sudden death in these individuals. TdP also occurs as a complication of drugs that prolong a cardiac timing interval by blockade of potassium channels. This list of drugs includes the antibiotics erythromycin, azithromycin, clarithromycin, levofloxacin and ciprofloxacin.

The assembled collection of biospecimens and the associated clinical/genetic data will be the foundation for experiments with the statistical power to provide the insights from the state of the art technologies in genomics and proteomics. If the collection doesn’t exist, the insights available from the new technologies cannot find their way to PAH research. While generating a biobank is not a new idea, what is new is the inventory and tracking system, the software, specimen extraction, and communication with users to implement the Best Practices applied to PAH.