Brain, Spinal Cord & Nervous System

ARCADIA is a multicenter, biomarker-driven, randomized, double-blind, active-control, phase 3 clinical trial of apixaban versus aspirin in patients who have evidence of atrial cardiopathy and a recent stroke of unknown cause. Eleven hundred subjects will be recruited over 2.5 years at 120 sites in the NIH StrokeNet consortium. Subjects will be followed for a minimum of 1.5 years and a maximum of 4 years for the primary efficacy outcome of recurrent stroke and the primary safety outcomes of symptomatic intracranial hemorrhage and major hemorrhage other than intracranial hemorrhage.

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The purpose of this study is to identify if and which cytokines are elevated in patients with a CSF infection. Additionally, we aim to determine which of these can transfer across the blood-brain-barrier and into the peripheral system where they then cause the levels of detectable leukocytes to rise in the peripheral circulation.

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The SCAN Lab is conducting a study at the University of Arizona to understand the cognitive and psychological health of people who have experienced brain injury or “concussion.”

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This is a study aimed at probing the brain's circuitry with the use of non-invasive neuroimaging and neuromodulation techniques. Specifically, we will use Transcranial Magnetic Stimulation (TMS) to briefly stimulate specific brain regions. TMS uses a strong magnet (about the same strength as an MRI machine). When applied repetitively, TMS is used as an FDA approved clinical therapy for drug-resistant cases of neurological conditions like depression. When applied in a single session (as is proposed in this study), there are no expected lasting effects of the TMS session.

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This research study is being done to find out if CIRARA can limit brain swelling and improve functioning in people who have had a large stroke. We also want to find out if CIRARA improves survival. Your progress will be measured using routine questionnaires and by examining pictures of your brain taken by MRI or CT. The study will also help to determine the side effects of CIRARA in patients with large stroke.

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The SLATE study will use the Medtronic VisualaseTM MRI-Guided Laser Ablation system. The Visualase system is used to perform minimally invasive laser surgery on soft tissue in the body. For neurosurgery, a surgeon guides a thin laser fiber through a small hole into the brain. The laser heats up and destroys a defined area of abnormal brain tissue minimizing risk of potential damage to surrounding healthy tissue. The patient is in a magnetic resonance imaging (MRI) scanner throughout the process.

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The purpose of this study is to test the effects of cromolyn sodium as an adjuvant treatment for post ischemic stroke cognitive impairment (PSCI). It is not known whether this drug will treat dementia and cognitive impairment. Cromolyn sodium is taken using a mouth inhaler device (similar to those used in the treatment of asthma) twice a day. There are 6 scheduled visits over a 12-week period. Each visit is expected to last approximately 3-4 hours.

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With IRB approval, we have completed 3 previous clinical transcranial ultrasound (TUS) studies on several hundred healthy human subjects without problems. The current study proposes to test effects of brief, sub-thermal TUS for memory, mood and cognition in patients with memory and/or cognitive dysfunction following brain injury (including concussion), and those who have, or may have, Alzheimer’s disease or other dementia.

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Induced pluripotent stem cells (iPSCs) are adult cells that have been genetically reprogrammed to be able to develop into the various cell types that make up the human body. Skin biopsies taken from pediatric patients with rare neurodegenerative disorders and age matched controls will be used to generate patient specific iPSC cell lines. These cell lines will then be developed into various neuronal cell populations in order to study the genetic cause of these rare and incurable diseases.

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The purpose of this study is to determine the feasibility of a blood test approach to prevent false diagnosis of Parkinson’s disease in essential tremor. This study is also being conducted to obtain blood samples to be stored in a biorepository. A biorepository is a collection of samples and health information that can be used by researchers for future studies.

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