This research is being done to see if a medicine used to treat high blood pressure, Losartan, can slow the damage to the lungs in people who have COPD with emphysema. Currently, there are some medications for COPD to reduce symptoms and prevent exacerbations. However, there are no treatments to slow or stop the progression of the disease.
The Oral Bacterial Extract (ORBEX) Study is a three year study to see whether the wheezing and lower respiratory tract illnesses that lead to asthma can be prevented. The goal is to find if a medication that is used in Europe, called Broncho-Vaxom®, can prevent wheezing lower respiratory infections in young children. It may work to stimulate a child’s immune system in order to increase the body’s defenses against germs that cause children to have respiratory illnesses.
We are looking for overweight individuals who have asthma and want to start working out regularly. Researchers believe that exercise may have a beneficial effect on inflammation and asthma symptoms in overweight people with mild to moderate persistent asthma. The purpose of this study is to see if a 12-week exercise program will affect inflammation, lung function, asthma symptoms, and asthma quality of life in overweight adults with asthma.
The Pediatric Acute Respiratory Distress Syndrome Incidence and Epidemiology (PARDIE) study is designed as a multi-center international observational, cross sectional study of new cases of PARDS involving 5 continuous days of screening and patient enrollment, occurring every 2 months for a year (6 total study weeks). Included patients will have a new diagnosis of PARDS during the study week or be at risk for PARDS. Data collection will concentrate on the first 3 days of PARDS diagnosis, and follow outcomes such as mortality and length of ventilation.
Coughing and wheezing are very common symptoms of childhood. Many children, up to 50% of wheeze at some time during the first 6 years of life.
Studies have shown that, even at 9-10 years, wheezy children may have decreased lung function. This early decrease in lung function may go on to cause problems and lung disease in adult life. This makes it very important to understand what causes cough and wheezing in young children.
Optimal delivery of nutritional support during critical illness is central to appropriate intensive care unit management, and yet fundamental gaps in knowledge exist regarding timing, route, dose, and type of nutritional support for critically ill infants and children. Understanding how to optimize nutritional support during pediatric critical illness is important because even brief periods of malnutrition in infancy result in permanent negative effects on long-term neurocognitive development.
The assembled collection of biospecimens and the associated clinical/genetic data will be the foundation for experiments with the statistical power to provide the insights from the state of the art technologies in genomics and proteomics. If the collection doesn’t exist, the insights available from the new technologies cannot find their way to PAH research. While generating a biobank is not a new idea, what is new is the inventory and tracking system, the software, specimen extraction, and communication with users to implement the Best Practices applied to PAH.
This study will look at how particular proteins are involved in asthma. Specifically, the study will examine specific proteins called surfactant protein A and D (SP-A, SP-D, which help with surface tension) and look at the way the natural molecules hyaluronan (HA) and Snitrosoglutathione reductase (GSNOR) affect inflammatory and immunologic responses in allergic asthma.