PrecISE, the Precision Interventions for Severe and/or Exacerbation-Prone Asthma Network, is a research study to understand how to treat different types of severe asthma. We are looking for people who have asthma attacks or frequent asthma symptoms. Everyone in the study will receive one or more study medicines for their severe asthma. This study is sponsored by the U.S. National Heart, Lung, and Blood Institute (NHLBI). This study is designed to investigate new treatments for asthma that are thought to work better in some patients than in others.