Trauma & Emergency Medicine

Bleeding is the most common cause of preventable death after injury in children. There have been no large studies to guide doctors in how best to care for children with life-threatening bleeding after trauma.

We are taking part in a national study to see what combination of treatments given soon after arrival in the emergency department can improve survival. The treatments include blood products (whole blood, red blood cells, plasma and platelets) and a medication that can help blood clot (tranexamic acid).

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Trauma is the leading cause of death in those under the age of 45 and the most common cause of preventable death after injury is bleeding. When someone is injured and they lose a lot of blood, they require an immediate blood transfusion.

When a person donates blood, it is typically separated into several components, such as red blood cells, plasma, platelets, and a few others. Injured patients who are bleeding require all of these parts, so it makes sense to use blood that has not been separated. This is called “Whole Blood”.

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Trauma is the leading cause of death in those under the age of 45 and the most common cause of preventable death after injury is bleeding. The CAlcium and VAsopressin following Injury Early Resuscitation trial (CAVALIER), is a study that will look at whether giving calcium, vasopressin or both earlier will increase survival for someone who is injured and bleeding badly.

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Trauma is the leading cause of death in those under the age of 45. The most common cause of preventable death after injury is bleeding, which is often accompanied by clotting factor abnormalities. Kcentra® (or 4-factor prothrombin complex concentrate) is a Food and Drug Administration (FDA) approved product that contains clotting factors.

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