phase III, randomized, double-blind, placebo-controlled, multicenter, 7-month study designed to assess the safety and efficacy of intramuscular (IM) injections in the calf of VM202 in patients with chronic nonhealing foot ulcers. Three hundred patients will be randomized in a 2:1 ratio of VM202 or placebo injections:
Active -VM202 + standard of care - 200 patients
Control - Placebo (VM202 Vehicle) + standard of care - 100 patients
We are looking for families with a child or adolescent with a diagnosis of type 1 diabetes to participate in a study examining the effects of an intervention to assist families with their daily routines. Assessments and the intervention consultation address sleep, school, and family activities that may help or interfere with diabetes management.
Insulin is the hormone, produced normally by the body, which causes blood sugar to return to normal after eating. Insulin resistance is a state when the body is not using insulin correctly, and more insulin is needed to keep the sugar level normal. Insulin resistance can lead to Type 2 Diabetes. Type 2 diabetes is a disease in which blood sugar levels are too high. Our studies of DNA methylation may help to find out why some people develop Type 2 Diabetes. By studying this, we hope to better understand the causes of insulin resistance.
Diabetes mellitus has been shown to be a predictor of poor outcomes in hospitalized trauma patients. The current methods used for in-hospital blood sugar control have been proven to be outdated and ineffective when used alone. Studies have shown that the more modern methods used for at home blood sugar control are much more effective at maintaining normal blood sugar levels.
In this study we are trying to find out why mitochondria and other proteins important to insulin signaling do not work well in muscle from people who are overweight or who have Type 2 Diabetes. Mitochondria are tiny bodies in all your cells that make energy and how insulin and exercise alter proteins that control energy production in skeletal muscle.
The purpose of this trial is to confirm the efficacy and safety of faster-acting insulin aspart as mealtime insulin as well as postmeal injected insulin in combination with insulin degludec in subjects with T1DM. The results will be used in the registration file in Japan and label updates globally on use of faster aspart in combination with insulin degludec. In the European Medicines Agency (EMA) and FDA note for guidance on clinical investigation of
medicinal products for the treatment of diabetes, HbA1c is considered the most widely accepted
This study will evaluate the effect of metformin at the usual target dose for patients with prediabetes and patients wirh type 2 diabetic on the plasma methylglyoxal (MG) and urine metformin-MG IMZ cyclized product (IMZ) levels, which will be compared to the MG and IMZ levels of the matched non-diabetic patients
The purpose of this study is to compare the effects, good and/or bad, of temozolomide versus temozolomide plus capecitabine on the subjects and the subjects’advanced pancreatic neuroendocrine tumor cancer to find out which is better. In this study, subjects will get either temozolomide alone or temozolomide and capecitabine. Temozolomide and capecitabine are chemotherapy drugs, which have benefited some patients with pancreatic neuroendocrine tumors yet they have never been compared; both arms are considered investigational.