Pathway to Prevention

Basic eligibility criteria:
Please contact the study coordinator for additional eligibility information.

Inclusion Criteria:

• Individuals 2 to 45 years old who have an immediate family member with type 1 diabetes (such as a child, parent, or sibling)
• Individuals 2 to 20 years old who have an extended family member with type 1 diabetes (such as a grandparent, half-sibling, cousin, niece, nephew, aunt, or uncle)
• Individuals 2 to 45 years old who are not family members of an individual with type 1 diabetes and are known to have 1 or more islet antibodies. These individuals are eligible for screening.

Exclusion Criteria:

To be eligible a person must not:

• Have diabetes already.
• Have previous or current history of being treated with insulin or oral diabetes medications.
• Currently using systemic immunosuppressive or immunomodulatory therapies, including pharmacologic doses of systemic steroids (may include topical and inhaled agents).
• Have any known serious diseases and/or diseases that are likely to limit life expectancy or lead to use of chronic immunocompromise or immunomodulatory therapies during the use of the study.