Understanding insulin resistance in obesity and type 2 diabetes
The molecular nature of insulin resistance in human muscle is still incompletely defined. For almost thirty years we have been trying to understand the mechanisms that explain why muscle in patients who are obese or have type 2 diabetes only poorly uses fat for fuel. We termed this metabolic inflexibility. This causes fat to build up in muscle and other tissues, and causes the patient to respond poorly to insulin. We now think there are two proteins, called ANT1 and VWA8, that might be responsible for at least part of this. The studies in this project are designed to provide evidence regarding the role of these two proteins in metabolic inflexibility.
Study phase: N/A
Basic eligibility criteria:
Please contact the study coordinator for additional eligibility information.
- Age: 21-60
- Male or Female
- For females: Not pregnant or breast feeding
- With or without Type 2 Diabetes
Contact study coordinator for additional eligibility criteria
Primary disease category: Diabetes & Endocrine System
Secondary disease categories: Healthy Volunteers
Protocol number: 1711048074
Projected enrollment dates: December 2018 to December 2023
Official study title: MOLECULAR REGULATION OF MUSCLE GLUCOSE METABOLISM (AIMS 1 AND 2, 2017)