Understanding insulin resistance in obesity and type 2 diabetes

The molecular nature of insulin resistance in human muscle is still incompletely defined. For almost thirty years we have been trying to understand the mechanisms that explain why muscle in patients who are obese or have type 2 diabetes only poorly uses fat for fuel. We termed this metabolic inflexibility. This causes fat to build up in muscle and other tissues, and causes the patient to respond poorly to insulin. We now think there are two proteins, called ANT1 and VWA8, that might be responsible for at least part of this. The studies in this project are designed to provide evidence regarding the role of these two proteins in metabolic inflexibility.

Study phase: N/A

Basic eligibility criteria:
Please contact the study coordinator for additional eligibility information.

  • Age: 21-60
  • Male or Female
    • For females: Not pregnant or breast feeding
  • With or without Type 2 Diabetes

Contact study coordinator for additional eligibility criteria

Primary disease category: Diabetes & Endocrine System

Secondary disease categories: Healthy Volunteers

Sponsor: NIH:NIDDK

Protocol number: 1711048074

Projected enrollment dates: December 2018 to December 2023

Official study title: MOLECULAR REGULATION OF MUSCLE GLUCOSE METABOLISM (AIMS 1 AND 2, 2017)