This study will look at how particular proteins are involved in asthma. Specifically, the study will examine specific proteins called surfactant protein A and D (SP-A, SP-D, which help with surface tension) and look at the way the natural molecules hyaluronan (HA) and Snitrosoglutathione reductase (GSNOR) affect inflammatory and immunologic responses in allergic asthma. It is hoped that the information learned from this study can help researchers obtain a better understanding of the roles of SP-A, SP-D, GSNOR and HA and their effect on airway remodeling (permanent destruction of the airway) in asthma

Basic eligibility criteria:
Please contact the study coordinator for additional eligibility information.

Adults with asthma.
Healthy adults.

Primary disease category: Asthma & Lung

This study is enrolling healthy volunteers.

Sponsor: NHLBI

Protocol number: P01-HL108793-01A1

Projected enrollment dates: March 2015 to December 2017

Official study title: Hyaluronan