Effects of Transcranial Ultrasound (‘TUS’) on Memory and Mood in Cognitively-Impaired Human Subjects

With IRB approval, we have completed 3 previous clinical transcranial ultrasound (TUS) studies on several hundred healthy human subjects without problems. The current study proposes to test effects of brief, sub-thermal TUS for memory, mood and cognition in patients with memory and/or cognitive dysfunction following brain injury (including concussion), and those who have, or may have, Alzheimer’s disease or other dementia. In this experiment, patients with memory dysfunction possibly due to dementia including Alzheimer’s disease and brain injury (including concussion) will be given ultrasound for cognitive enhancement and mood improvements. They will receive two minutes of low intensity TUS to right and two to the left temporal window twice a week for four weeks. A full battery of tests will be administered at the beginning and end of the four weeks, and a minor test battery after each exposure.

Study phase (if other): Pilot

Basic eligibility criteria:
Please contact the study coordinator for additional eligibility information.

Alzheimer's disease
Dementia
Mild Cognitive Impairment
Traumatic Brain Injury
Concussion

Primary disease category: Brain, Spinal Cord & Nervous System

Projected enrollment dates: January 2016 to January 2017

Official study title: Effects of Transcranial Ultrasound (‘TUS’) on Memory and Mood in Cognitively-Impaired Human Subjects