Cortical Sensorimotor Mechanisms of Carpal Tunnel Syndrome

Carpal Tunnel Syndrome (CTS) remains an elusive, unsolved medical problem.  Current mainstream approaches address the problem at the site of symptoms, but this approach only partially accounts for the causes and effects of CTS.  Growing evidence suggests that CTS impacts not only the nervous system at the hand, but also impacts the brain. We propose that altered representation of the fingers and thumb in the brain can prolong sensory symptoms and make using the hand more difficult which perpetuates the loss of function.  We will compare MRI images of the brain for CTS patients with images for healthy controls.

Study phase: Other

Study phase (if other): rehabilitation, mechanistic clinical trial

Basic eligibility criteria:
Please contact the study coordinator for additional eligibility information.

Inclusion for all participants:  Age 21-65 years old, BMI less than 30

Inclusion for CTS Participants:  Diagnosed with CTS (study does not pay for diagnosis), current symptoms

Inclusion for healthy participants:  Gender, Age and BMI matched to CTS participant (keep calling back)

Exclusion for all participants:  CTS release surgery, injury or neuro problem affecting the hand, systemic disease

Primary disease category: Brain, Spinal Cord & Nervous System

This study is enrolling healthy volunteers.

Sponsor: NIH

Protocol number: 2003430397

Projected enrollment dates: April 2020 to August 2025

Official study title: Cortical Sensorimotor Mechanisms of Carpal Tunnel Syndrome